Ipilimumab plus nivolumab in patients with symptomatic melanoma brain metastasis requiring corticosteroids

•Metastatic melanoma frequently presents with symptomatic brain metastasis.•Ipilimumab plus nivolumab has modest efficacy in those patients.•Responding patients to ipilimumab plus nivolumab may derive long-term benefit.•Even patients with high-dose corticosteroids may respond to ipilimumab & nivolumab.