Recommendations for the use of next-generation sequencing in patients with metastatic cancer in the Asia-Pacific region: a report from the APODDC working group

•Clinical adoption of NGS is heterogeneous in the APAC region due to diversity in access, practice guidelines, and funding.•The APODDC group recommends routine NGS testing for daily practice in patients presenting with advanced NSCLC.•Routine multigene NGS testing is not recommended in metastatic GC, cholangiocarcinoma, NPC, BC, and HCC.•In research centres with molecular screening programs, NGS can enhance understanding of promising targets in OC.•Allele-specific PCRs or a small-panel, multiplex-gene NGS testing was suggested to identify key alterations in CRC.