Toxicological mechanism of triptolide-induced liver injury: Caspase3-GSDME-mediated pyroptosis of Kupffer cell

Chenyang Han,Hongyan Pei,Yongjia Sheng,Jin Wang,Xiaohong Zhou,Wenyan Li,Li Guo,Yun Kong,Yi Yang

Ecotoxicology and Environmental Safety（2023）

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摘要

•TRI can promote Caspase-3 maturation and regulate kupffer cell pyroptosis.•The binding of TRI, a Caspase-3 activator, to VAL27 site promoted the maturation and cleavage of Cleaved-Caspase-3.•TRI activated Caspase-3-GSDME in tissues and elevated the levels of N-GSDME and Cleaved-Caspase-3.

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关键词

Triptolide,Liver injury,Kupffer cell,Pyroptosis,Caspase-3

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