The dynamic changes of monocytes and cytokines during wound healing post-burn injury

Cytokine(2023)

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摘要
•BCA-1 is a novel cytokine in burn wound healing but has significant changes.•MCP-1 and IL-6 levels have a positive correlation with burn severity.•CD14+ CD16+ reaches higher levels during more severe burn injury and in hypertrophic scar patients, contributing to the pro-inflammatory response.•IL-8 antagonism may prove beneficial in curbing excessive inflammation leading to fibrotic scars.•IL-1RA appears to be an anti-inflammatory mediator after burn injury.
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关键词
Burns,Monocytes,SDF-1/CXCR4,MCP-1/CCR2,RANTES/CCR5,Wound healing,scarring,hypertrophic,IL-6,IL-8,IL-1RA,BCA-1,chemokines,cytokines
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