Effect of Diabetes Mellitus on Survival in Patients with Gallbladder Cancer: A Systematic Review and Meta-analysis

Abstract Background Increasing evidences indicate that diabetes may increase the incidence of gallbladder cancer. However, no sufficient data clarify the effect of diabetes on survival in patients with gallbladder cancer.Methods We comprehensively search PubMed, Embase, and the Cochrane Library databases through July 2019 in order to find sufficient eligible researches. The pooled hazard risks (HRs) and relative risks (RRs) with 95% confidence intervals (CIs) were calculated with either fix-effects or random-effects model.Results Ten eligible studies were included in this meta-analysis. Analysis of eight cohorts found that diabetes was closely associated with the mortality of gallbladder cancer (HR=1.10; 95% CI: 1.06-1.14; P<0.00001). However, no significant differences were found between male and female diabetes patients (RR=1.08, 95%CI=0.57-2.04, P=0.80).Conclusions These findings indicate that diabetes patients have a higher mortality of gallbladder cancer compared with non-diabetes and general population.