Impaired DNA double-strand break repair and effective radiosensitization of HPV-negative HNSCC cell lines through combined inhibition of PARP and Wee1

Agnes Oetting,Sabrina Christiansen,Fruzsina Gatzemeier,Sabrina Köcher,Lara Bußmann,Arne Böttcher,Katharina Stölzel,Anna Sophie Hoffmann,Nina Struve,Malte Kriegs,Cordula Petersen,Christian Betz,Kai Rothkamm,Henrike Barbara Zech,Thorsten Rieckmann

Clinical and Translational Radiation Oncology（2023）

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摘要

•Effective radiosensitization of HPV- HNSCC cells through targeting of PARP and Wee1.•Enhanced radiation-induced DNA damage levels conferred by dual targeting.•Ex vivo tumor slice cultures may predict individual patients‘ responsiveness.

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关键词

effective radiosensitization,impaired dna,double-strand,hpv-negative

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