546. Role of Glia in Environment-Environment Interaction: Focus on Dopaminergic Neurotransmission in the Striatum

Maternal immune activation (MIA) and adolescent cannabis use are associated with psychiatric conditions later in life. We hypothesized that MIA would interact with adolescent exposure to delta-9-tetrahydrocannabinol (THC) to synergistically produce neurobehavioral abnormalities in adulthood.