An upconversion nanoplatform based multi-effective theatment for Parkinson’s disease

•Oxidative stress and neuroinflammation are the key mechanisms in the occurrence and development of PD.•Precise controlled release of drug in the brain based on UCNP under near-infrared irradiation for the treatment of PD.•Controlled drug delivery to target the PD microenvironment through lactoferrin.•Combining NO nanocarriers (short-term) and traditional Chinese medicine Pae (long-term) achieved synergistic treatment of PD.