473. Altered Cerebral Neurometabolic Response to Methylene Blue in Bipolar Disorder

Alfonso Russo,Balazs Örzsik,Ivor Simpson, Prince Nwaubani,Antonello Pinna,Riccardo De Marco, Amy Kartar,Nisha Singh,Fernando Zelaya,Nefize Yalin,Allan H. Young,Mara Cercignani,Iris Asllani,Alessandro Colasanti

Biological Psychiatry（2023）

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摘要

Electron transport chain (ETC) abnormalities have been reported in the frontal lobe of bipolar disorder patients (BD). Methylene blue (MB) is proposed to affect neuronal metabolism by providing an alternative electron transfer pathway at mitochondrial ETC level. We used quantitative neuroimaging to study the effects of an acute MB administration on cerebral oxygen metabolism in BD patients in regions relevant to its pathophysiology.

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methylene blue,bipolar disorder,altered cerebral neurometabolic response

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