315. Disease-Informed Assessment Identifies Robust Brain Correlates of Cognitive Performance in Psychosis and its Prodrome

Neurocognitive impairment is a well-known phenomenon in schizophrenia that begins prior to psychosis onset. Analyses of traditional cognitive tasks have identified inconsistent biological links to cognitive deficits. Unlike traditional tasks, the auditory continuous performance task (ACPT) measures cognitive deficits specific to psychotic disorders. Using this disease-informed measure, we conducted a connectome-wide analysis to identify psychosis-specific circuits of cognitive performance.