Self-oriented ferritin nanocages mitigate iron overload-induced oxidative stress for acute kidney injury

Xuefang Lou,Jingyi Lu,Chen Wang,Yanling Song,Luwen Zhu,Yuchan You,Jucong Zhang,Jiahao Hu,Xinyi Xu,Xiaoling Xu,Yongzhong Du

Chemical Engineering Journal（2023）

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摘要

•Iron overload and overproduction of ROS are the main pathological mechanisms of AKI.•Ferritin can demineralized to prepare nanocarriers to encapsulate curcumin.•Ferritin-based nanocarriers have natural renal targeting ability.•Ferritin can transport toxic Fe2+ into the cavity to alleviate ferroptosis.

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关键词

Ferritin nanocages,Curcumin,Acute kidney injury,Ferroptosis,Tubular epithelial cell

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