Vector Aided Microenvironment programming (VAMP): reprogramming the TME with MVA virus expressing IL-12 for effective antitumor activity.

Laura Seclì,Luigia Infante,Linda Nocchi,Maria De Lucia,Gabriella Cotugno,Guido Leoni,Elisa Micarelli,Irene Garzia,Lidia Avalle, Giulia Sdruscia,Fulvia Troise,Simona Allocca,Giuseppina Romano,Elisa Scarselli,Anna Morena D'Alise

Journal for immunotherapy of cancer（2023）

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摘要

Intratumoral administration of MVA-IL-12 turns immunologically 'cold' tumors 'hot' and overcomes resistance to programmed cell death protein-1 blockade.

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关键词

tumor microenvironment, immunotherapy, cytokines, immunomodulation, lymphocytes, tumor-infiltrating

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