Controlled lipid self-assembly for scalable manufacturing of next-generation immune stimulating complexes

Chemical Engineering Journal(2023)

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摘要
•Developed new scalable method to synthesize next-generation ISCOMs.•ISCOMs assembled via controlled dilution from surfactant micelles.•Tangential flow filtration enabled rapid purification of product.•Saponin fraction influences ISCOM assembly conditions.
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关键词
Vaccines,Adjuvants,Immune stimulating complexes,Saponin,SMNP,Monophosphoryl lipid A,Tangential flow filtration
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