NIR responsive composite nanomaterials with in-situ deposition of cascaded nanozymes for multiple synergistic therapy of bacterial infection in diabetic mice

•This visualized therapeutic platform can eradicate and accurately image bacteria, and real-time monitor treatment progress.•The aptamer functionalized and NIR responsive CuS@Pt-Au/Apt NPs integrate targeting/CDT/PTT for bacterial infection therapy.•This research addresses the application limitation of nanozymes and effectively treats chronic wounds in diabetic mice.