93. Imaging the Neuroimmune Response After Repeated Traumatic Brain Injury

In those with repeated traumatic brain injury (TBI), chronic neuroimmune response may be linked to later onset of memory impairment. Former National Football League (NFL) players have history of repeated TBI incurred through contact sport. [11C]DPA-713 PET (DPA-PET) is a promising neuroimaging technique to quantitatively localize the hypothesized high expression of translocator protein (TSPO), a marker of brain injury and repair, in former NFL players. Here we used DPA-PET in a large cohort of NFL players who left the NFL in the past 10 years, and tested for change in TSPO over time.