CircHULC accelerates the growth of human liver cancer stem cells by enhancing chromatin reprogramming and chromosomal instability via autophagy

Shuting Song,Liyan Wang,Xiaoxue Jiang,Xinlei Liu,Shujie Li,Sijie Xie,Dongdong Lu

Cellular Signalling（2023）

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摘要

•CircHULC enhances the methylation modification of PKM2 via CARM1 and the deacetylase Sirt1.•CircHULC affects the expression of chromatin reprogramming factors and oncogenes through autophagy.•CARM1 and Sirt1 determine the cancerous function of CircHULC dependent on autophagy.

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关键词

CircHULC, Human liver cancer stem cells, Autophagy, CARM1, PKM2, Sirt1

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