Downregulation of RAB17 have a poor prognosis in kidney renal clear cell carcinoma and its expression correlates with DNA methylation and immune infiltration

•RAB17 is lowly expressed in kidney renal clear cell carcinoma (KIRC).•RAB17 may be epigenetically regulated through DNA methylation in KIRC.•RAB17 expression is strongly associated with immune cell infiltration in KIRC.•In vitro, silencing of RAB17 promoted KIRC cell migration.•RAB17 cloud be a potential prognostic biomarker for KIRC patients.