Mocravimod, a S1P receptor modulator, increases T cell counts in bone marrow biopsies from patients undergoing allogeneic hematopoietic stem cell transplantation

Simone Dertschnig,Jakob Passweg,Christoph Bucher,Michael Medinger,Alexandar Tzankov

Cellular Immunology（2023）

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摘要

•First study that investigated lymphocyte retention by S1P modulation in bone marrow.•Mocravimod causes T cells to accumulate in the bone marrow.•CD4+ T cells are more sensitive to mocravimod treatment than CD8+ T cells.•Favourable overall survival in alloHCT patients with mocravimod.

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关键词

Allogeneic hematopoietic cell transplantation, Graft-versus-host disease, Mocravimod, Sphingosine-1-phosphate receptor, T cells, Bone marrow biopsies

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