Weaponizing the proteasome to overcome antimalarial drug resistance
Cell Chemical Biology(2023)
摘要
In this issue of Cell Chemical Biology, Zhan et al. report dual-pharmacophore molecules ("artezomibs"), combining an artemisinin and proteasome inhibitor that exhibit potent activity against both wild-type and drug-resistant malarial parasites. This study indicates that artezomibs offer a promising approach to combat drug resistance encountered by current antimalarial therapies.
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关键词
proteasome,drug resistance
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