Runoff variations affected by climate change and human activities in Yarlung Zangbo River, southeastern Tibetan Plateau

•Runoff changes in the Yarlung Zangbo River Basin were attributed based on the Budyko framework.•78.81% of runoff changes is attributed to climate change and 21.19% to human activities.•Increasing precipitation and accelerating snowmelt may not offset water dissipation induced by rising temperature.•Combined effects of multiple factors on runoff were explored.•Precipitation is the best predictor of runoff variations in the region.