A Non-Hallucinogenic LSD Analogue With Therapeutic Potential in Mood Disorders

Vern Lewis,Emily Arsenault, Mario Alberto Bautista-Carro,Fatimeh-Frouh Taghavi-Abkuh,Fatema El Sayegh,Argel Aguilar Valles

Biological Psychiatry（2023）

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摘要

Serotonergic psychedelics are emerging as alternative therapies for treatment-resistant depression, however, their hallucinogenic potential limits widespread clinical use. Second-generation psychedelics, which lack hallucinogenic effects, are a promising alternative. 2-Bromo-LSD (2-Br-LSD/BETR-001) is an LSD derivative with 5-HT2A partial agonist activity that lacks hallucinogenic effects. Thus, 2-Br-LSD may represent a possible novel therapeutic for treating neuropsychiatric diseases.

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关键词

Serotonergic Psychedelics,Major depression disorder,Chronic Variable Stress,2-Bromolysergic acid diethylamide

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