69. Lower Grey Matter Volume is not Related to Synaptic Density in Late Life Depression

Thomas Vande Casteele,Maarten Laroy,Margot Van Cauwenberge,Michel Koole,Patrick Dupont,Stefan Sunaert,Jan Van den Stock,Filip Bouckaert,Koen Van Laere,Louise Emsell,Mathieu Vandenbulcke

Biological Psychiatry（2023）

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摘要

Late life depression has been consistently associated with lower grey matter volume, the cause of which remains largely unexplained. We hypothesized that lower grey matter volume would be linked to synaptic deficits due to pathological brain ageing. Here, we investigate synaptic density for the first time in vivo in late life depression using the synaptic vesicle 2A receptor radioligand 11C-UCB-J.

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lower grey matter volume,synaptic density,depression

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