renatal Maternal Inflammation, Cognition in Childhood, and Adolescent Depressive Symptoms

Accumulating evidence indicates that higher prenatal maternal inflammation (PNMI) is associated with increased depression risk in adolescent and adult-aged offspring. PNMI may prime individuals for a cascade of pre/postnatal adversities across development, including impaired cognitive abilities, which in turn may heighten risk for depression onset. Therefore, this study explored the potential mediating role of childhood cognition in the relationship between PNMI and adolescent depressive symptoms.