18. Short-Term Mood Effects of Repeated Propofol Infusions for Depression

The anesthetic propofol is proposed to have antidepressant effects. Although propofol has been observed to induce short-term positive mood effects during routine clinical use, the dose-dependent effects of repeated infusions with depressed subjects remains unknown. We hypothesized that immediate drug-induced mood improvements would change with repeated infusions and that immediate improvement would predict later antidepressant response.