43. Acute Effects of MDMA on Intrinsic Functional Connectomes Associated With Altered States of Consciousness and Defensiveness

Xue Zhang,Laura Hack,Boris Heifets,Trisha Suppes,Peter van Roessel,Jerome Yesavage,Nancy Gray,Rachel Hilton,Carolyn Rodriguez,Karl Deisseroth,Brian Knutson,Leanne Williams

Biological Psychiatry（2023）

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摘要

3,4-Methylenedioxymethamphetamine (MDMA), a serotonin releaser, reduces interpersonal defensiveness but is also thought to open a “critical period” in the brain in which alterations in consciousness may enhance a therapeutic process. However, the relationship between MDMA-induced effects on brain connectomes and these altered states has not been directly examined.

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关键词

MDMA, BOLD functional MRI, Intrinsic Connectivity Networks, Altered State of Consciousness, Mechanistic Study

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