Age-associated systemic factors change central and peripheral immunity in adult male mice
Brain, Behavior, and Immunity(2023)
摘要
•We provide a comprehensive overview of the central and peripheral immune landscape of adult and aged male mice.•We found that CD8+ T cells expressing programmed cell death protein 1 (PD1) and tissue-resident memory CD8+ T cells accumulate in the aged mouse brain.•We establish immune correlation networks between peripheral and central immune cells, and found that these networks are enriched for associations between circulating CD8+ T cells and brain-derived immune cells in aged mice.•We show that exposure to age-associated systemic factors induces the expansion of memory T cells in the periphery and CD8+ T cells in the white matter.
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关键词
peripheral immunity,systemic factors,mice,age-associated
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