Incident racial discrimination predicts elevated C-Reactive protein in the Black Women’s experiences Living with Lupus (BeWELL) study

•Research on racial discrimination and inflammation is limited by an absence of longitudinal studies.•We examined incident racial discrimination and CRP among Black women with systemic lupus erythematosus.•Bi-annual assessment of self-reported racial discrimination reduced recall bias.•Incident experiences of racial discrimination forecasted increased CRP.•Racial discrimination may contribute to SLE inequities via inflammatory pathways.