Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis

Gagan D. Flora,Manasa K. Nayak,Madankumar Ghatge,Mariia Kumskova,Rakesh B. Patel,Anil K. Chauhan

Blood Advances（2023）

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摘要

•Combined deletion of pyruvate dehydrogenase kinase (PDK) 2 and 4 inhibits platelet function and arterial thrombosis.•PDK2/4 contributes to platelet biology by regulating pyruvate dehydrogenase phosphorylation and aerobic glycolysis in activated platelets.

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mitochondrial pyruvate dehydrogenase kinases,platelet function,thrombosis

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