Exosomal circ-CTNNB1 derived from colorectal cancer cells induces N2 polarization of neutrophils to promote colorectal cancer cell growth and immune escape

Liang Wang,Yuqiang Shan,Sixin Zheng,Jiangtao Li,Akao Zhu

Biomedical Signal Processing and Control（2023）

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摘要

•Circ-CTNNB1 was first confirmed to promote CRC cell growth and immune escape.•Exosomal circ-CTNNB1 was verified to induce N2 polarization of neutrophils.•Circ-CTNNB1 was unveiled to enable neutrophils to exert cancer-promoting effect.•Circ-CTNNB1 was proved to activate NF-κB pathway via miR-3619-5p/IKBKB axis.•Circ-CTNNB1 was verified to up-regulate PD-L1 by activating NF-κB pathway.

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关键词

circ-CTNNB1, NF-kappa B signaling pathway, N2 polarization, Colorectal cancer, Immune escape

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