Design and synthesis of N-acyl and dimeric N-Arylpiperazine derivatives as potential antileishmanial agents

Activity data analysis out of twenty nine compounds, 4a, 4d and 4e demonstrated excellent inhibition activity with both promastigote and amastigote form of L. donovani. Results demonstrated that compound 4d (amastigote IC50 = 2.0 µM, SI = 42) is a promising lead candidate for further development as antileishmanial drug.