An Enigma Mega-Analysis of Cortical Structure and Subcortical Volumes in Youths With Conduct Disorder: Influence of Sex, Callous-Unemotional Traits and AgeOf-Onset

Meta-analyses have shown that conduct disorder (CD) is associated with lower grey matter in cortical and subcortical regions. However, those meta-analyses were limited in sample sizes and their ability to assess how sex and subtypes of CD (e.g., callous-unemotional traits and age-of-onset) were associated with brain structure. Here, through the ENIGMA- Antisocial Behavior working group, we assembled 20 different cohorts worldwide to conduct a mega-analysis of cortical structure and subcortical volumes in youths with CD and systematically examine how sex and CD subtypes were related to those brain metrics.