Discovery of diaminotriazine carboxamides as potent inhibitors of hematopoetic progenitor kinase 1

Lixin Zhou, Xiuquan Ye,Kaizhen Wang, Hongtao Shen,Tianyu Wang,Xiangyu Zhang,Sheng Jiang,Yibei Xiao,Kuojun Zhang

Bioorganic Chemistry（2023）

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摘要

•A series of diaminotriazine carboxamides as HPK1 inhibitors were designed and synthesized.•Compound 15b was identified as the most active HPK1 inhibitor.•Compound 15b induced PBMCs to release IL-2 and IFN-γ.•Compound 15b demonstrated potent antitumor efficacy in MC38 tumor models.

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关键词

diaminotriazine,hematopoetic progenitor kinase,potent inhibitors

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