Novel flavonoid 1,3,4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway

Hua-Wen Meng, Zhen-Bao Shen,Xian-She Meng, Leng-Wei,Ze-Qun Yin,Xue-Rui Wang,Ting-Feng Zou,Zhi-Gang Liu,Tian-Xiang Wang,Shuang Zhang,Yuan-Li Chen,Xiao-Xiao Yang,Qing-Shan Li,Ya-Jun Duan

Bioorganic Chemistry（2023）

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摘要

•Flavone 1,3,4-oxadiazole derivatives act as anti-inflammatory and anti-oxidant agents for treating Parkinson's disease.•The optimal compound F12 is obtained through SAR optimization.•Compound F12 significantly reduces oxidative stress and inflammation via Nrf2/ NF-κB signaling pathway.•Compound F12 improves MPTP-induced Parkinson's disease in vivo.

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关键词

Flavone, 4-oxadiazole, Parkinson's disease, Oxidative stress, Nrf2, NF-& kappa,B

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