Construction of HPQ-based activatable fluorescent probe for peroxynitrite and its application in ferroptosis and mice model of LPS-induced inflammation

Yuxiang Ji,Sha Liu,Jian Zhang, Linruikang Qu,Jinsheng Wu,Heng Liu,Ziyi Cheng

Bioorganic Chemistry（2023）

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摘要

•A novel near-infrared ratio detection platform HPQD was designed for monitoring ONOO− level fluctuations.•HPQD was capable of imaging exogenous and endogenous ONOO− in A549 cells.•HPQD was successfully applied to monitor the level changes of ONOO− in ferroptosis and mice model of LPS-induced inflammation.

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关键词

peroxynitrite,activatable fluorescent probe,fluorescent probe,ferroptosis,inflammation,hpq-based,lps-induced

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