Physicochemical cues are not potent regulators of human dermal fibroblast trans-differentiation

Christina N.M. Ryan,Eugenia Pugliese,Naledi Shologu,Diana Gaspar,Peadar Rooney,Md Nahidul Islam,Alan O'Riordan,Manus J. Biggs,Matthew D. Griffin,Dimitrios I. Zeugolis

Biomaterials and Biosystems（2023）

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摘要

•Anisotropic surface topography induced bidirectional cell morphology on rigid substrates.•Macromolecular crowding increased various collagen types, but not fibronectin, deposition.•Physicochemical cues did not induce human dermal fibroblast trans-differentiation.

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关键词

Collagen type I coating,Surface topography,Substrate rigidity,Macromolecular crowding,In vitro microenvironment,Fibroblast plasticity

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