Superparamagnetic iron oxide nanoparticles target BxPC-3 cells and silence MUC4 for the treatment of pancreatic cancer

Yu Pu, Helin Ke,Changqiang Wu,Shaodan Xu,Yang Xiao,Lina Han, Guorong Lyu,Shilin Li

Biochimica et Biophysica Acta (BBA) - General Subjects（2023）

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摘要

•The PEI-SPION vector designed by us has been proved to be a positively charged nanocluster structure, which can automatically compound and release siRNA.•In vitro magnetic resonance imaging, the molecular probe has good T2 relaxation efficiency.•This study investigated the use of superparamagnetic iron oxide nanoparticles in treating and diagnosing pancreatic cancer

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关键词

Molecular probes,Pancreatic cancer,Gene therapy,siRNA,MUC4

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