Aspirin loaded extracellular vesicles inhibit inflammation of macrophages via switching metabolic phenotype in periodontitis

Yuanyuan Shi,Ruijie Zhang,Ningning Da,Yiming Wang,Jianhua Yang,Bei Li,Xiaoning He

Biochemical and Biophysical Research Communications（2023）

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摘要

•Macrophages play a key role in regulation of inflammatory response in periodontitis.•Aspirin-loaded extracellular vesicles (EVs-ASP) is a new drug delivery method in periodontitis treatment.•EVs-ASP polarizes macrophages from pro-inflammatory to anti-inflammatory phenotype.•EVs-ASP switches the metabolic process of macrophages from glycolysis to OXPHOS.

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