CMTM3 deficiency induces cardiac hypertrophy by regulating MAPK/ERK signaling

Jingjing Ye,Saifang Yan,Ruxia Liu,Lin Weng,Bo Jia,Shi Jia,Yufei Xiong,Yiqing Zhou,Minghong Leng,Junhui Zhao,Fenghe Yang, Ming Zheng

Biochemical and Biophysical Research Communications（2023）

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摘要

CMTM3 deficiency induces cardiac hypertrophy and aggravates hypertrophy and impaired cardiac function stimulated by angiotensin Ⅱ infusion. The expression of CMTM3 increases during cardiac hypertrophy, and the increased CMTM3 can inhibit further hypertrophy of cardiomyocytes by inhibiting MAPK signaling. Thus, CMTM3 plays a negative regulatory effect in the occurrence and development of cardiac hypertrophy.

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关键词

cardiac hypertrophy,deficiency,mapk/erk

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