Macrophage scavenger receptor A1 antagonizes abdominal aortic aneurysm via upregulating IRG1

Jianan Huang,Yunlong Jiang, Ruiyuan Ji, Yutian Jia,Saiya Wang,Zhongqiu Zhou,Siying Wang,Jie Wang,Qing Yang,Hui Bai,Xudong Zhu,Bin Jiang,Jingjing Ben,Hanwen Zhang,Xiaoyu Li,Qi Chen

Biochemical Pharmacology（2023）

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摘要

Our study reveals a protective effect of macrophage SR-A1-STAT3-IRG1 axis against aortic aneurysm formation via inhibiting inflammation.

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关键词

AAA,Ang II,ApoE,α-SMA,BMDM,BMT,ChIP,ECAR,ECM,EVG,FACS,FBS,GAPDH,H&E,IL-1β,IL-6,IRG1,KO,MCP-1,MMP,NOS2,Nrf2,4-OI,OCR,PMs,SEM,STAT3,SR-A1,TGF-β,TIMP-1,TNF-α,VSMC,WT

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