A flavonolignan, flavonoids and alkylamides from the fruits of Zanthoxylum Motuoense Huang

Chemical investigation on the fruits of Zanthoxylum motuoense have led to the isolation of a new flavonolignan (1), together with three known flavonoids (2-4), as well as five alkylamides (5–9). Their structures were determined by NMR, IR, UV, CD spectra and HRESIMS data. The chemotaxonomic significance of these compounds was discussed. The neuroprotective activity of the isolated compounds were evaluated. Compound 6 showed a significant protective effect against corticosterone-induced neuronal damage at 20 μmol/L.