Corrigendum to “Phospholipid transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis is directly correlated with HDL-cholesterol levels and is not associated with cardiovascular risk” [Atherosclerosis 324C (2021) 1–8]

In the Results section of this article (paragraph 6 in page 5), the values of DiI transfer to HDL of 3.0 ± 0.9 and 8.0 ± 5.7% (p < 0.001 vs. controls) observed in homo- (n = 4) and heterozygous (n = 3) Tangier subjects, respectively, were erroneously reported without normalization to the values of DiI transfer to reference HDL. Following such normalization, the values of DiI transfer were 10.0 ± 2.9% and 26.3 ± 18.7%, respectively (p < 0.001 vs. controls). This correction does not influence the statement of the paragraph as the p-values of the between-group differences were not modified by the correction. Overall conclusions of the manuscript are not affected either. The paragraph in question should read as follows: To verify that the reduction in DiI transfer to HDL observed in AMI patients was unrelated to their acute phase state, we recruited another group of low HDL-C subjects with Tangier disease (n = 7). Both HDL-C levels (2.2 ± 0.5 and 39 ± 11 mg/dL, p < 0.001 and p < 0.05, respectively, vs. controls) and DiI transfer to HDL (10.0 ± 2.9% and 26.3 ± 18.7%, p < 0.001 vs. controls) were significantly reduced in both homo- (n = 4) and heterozygous (n = 3) Tangier subjects, respectively. The authors sincerely apologize for this inaccuracy. Phospholipid transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis is directly correlated with HDL-cholesterol levels and is not associated with cardiovascular riskAtherosclerosisVol. 324PreviewWhile low concentrations of high-density lipoprotein-cholesterol (HDL-C) represent a well-established cardiovascular risk factor, extremely high HDL-C is paradoxically associated with elevated cardiovascular risk, resulting in the U-shape relationship with cardiovascular disease. Free cholesterol transfer to HDL upon lipolysis of triglyceride-rich lipoproteins (TGRL) was recently reported to underlie this relationship, linking HDL-C to triglyceride metabolism and atherosclerosis. In addition to free cholesterol, other surface components of TGRL, primarily phospholipids, are transferred to HDL during lipolysis. Full-Text PDF