Duox mediated ROS production inhibited WSSV replication in Eriocheir sinensis under short-term nitrite stress

Rui Jia,Xiaoling Dai,Yanfang Li, Xintong Yang,Xiuwen Min,Derun Quan,Peng Liu,Xin Huang,Jiachun Ge,Qian Ren

Aquatic Toxicology（2023）

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摘要

•A novel Duox gene (designated as EsDuox) was identified from Eriocheir sinensis.•Nitrite stress activates the expression of EsDuox that induces the production of ROS.•The synthetic ROS activates Dorsal that further regulates the expression of AMPs.•Inhibited replication of WSSV in crabs under 48 h nitrite stress was found.

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关键词

Nitrite stress,Duox,ROS,Antimicrobial peptides,WSSV,Eriocheir sinensis

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