Bacterial clearance and anti-inflammatory effect of Withaferin A against human pathogen of Staphylococcus aureus in infected zebrafish

Raghul Murugan, Senthil Subramaniyan,Snega Priya,Chinnasamy Ragavendran,Mariadhas Valan Arasu,Naif Abdullah Al-Dhabi,Ki Choon Choi,Ajay Guru,Jesu Arockiaraj

Aquatic Toxicology（2023）

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摘要

•Withaferin a inhibits growth of S. aureus though cell membrane damage.•Tube adherence test indicated biofilm inhibition by withaferin a at Sub-MIC concentration.•Treatment of withaferin a reduced inflammation in S. aureus infected zebrafish.•Protection from pathogen-induced cellular damage by withaferin a treatment was observed through histology analysis.

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staphylococcus aureus,human pathogen,bacterial clearance,anti-inflammatory

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