Manganese abated indomethacin-induced gastrohepatorenal toxicities in Rats via suppression of oxidative stress, polyamine catabolism, inflammation and activation of Caspase-3
Advances in Redox Research（2023）
摘要
•Multi-organ toxicity in rats is caused by indomethacin.•Manganese suppresses polyamine catabolism and caspase-3 activation.•Fibrogenesis occurs in indomethacin-induced toxicity.•Manganese has anti-fibrotic potential and inhibits inflammation.
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关键词
gastrohepatorenal toxicities,oxidative stress,manganese,inflammation,indomethacin-induced
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