Hypersensitivity infusion-associated reactions induced by enzyme replacement therapy in a cohort of patients with late-onset Pompe disease: An experience from the French Pompe Registry

Lola E.R. Lessard,Céline Tard,Emmanuelle Salort-Campana,Sabrina Sacconi,Anthony Béhin,Guillaume Bassez,David Orlikowski,Philippe Merle,Sylvain Nollet,Laure Gallay,Frédéric Bérard,Philip Robinson,Françoise Bouhour,Pascal Laforêt

Molecular Genetics and Metabolism（2023）

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摘要

•Most hypersensitivity reactions were Grade I and due to non-IgE hypersensitivity.•Most hypersensitivity reactions occurred in female LOPD patients.•Hypersensitivity reactions may occur after one year of well-tolerated ERT.•Modified regimen and desensitization were safe and effective to reintroduce ERT.

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hypersensitivity,enzyme,disease,replacement therapy,infusion-associated,late-onset

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