In vitro activity, ultrastructural analysis and in silico pharmacokinetic properties (ADMET) of thiazole compounds against adult worms of Schistosoma mansoni

Débora Verônica Sarmento Pereira da Silva, Pedro Henrique do Bomfim Nascimento, João Victor Ritinto da Rocha,Diego Santa Clara Marques,Fábio André Brayner,Luiz Carlos Alves,Hallysson Douglas Andrade de Araújo,Iranildo José da Cruz Filho,Mônica Camelo Pessoa de Azevedo Albuquerque,Maria do Carmo Alves de Lima,André de Lima Aires

Acta Tropica（2023）

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摘要

•Thiazole compounds have favorable bioavailability profiles.•Thiazoles promote moderate to low cytotoxicity against mammalian cells.•Thiazoles are promising schistosomal agents.

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