Serum Iron for Prognosis of Acute Ischemic Stroke by Endovascular Treatment

Abstract Background Iron, as an import micronutrient, is related to many diseases in a human body. Although the function of iron in acute ischemic stroke is yet debatable, there are few reports from clinical data on serum iron for the prognosis of acute ischemic stroke by endovascular treatment. The current retrospective study aimed to investigate the correlation between serum iron and acute ischemic stroke prognosis by endovascular treatment.Methods This study was carried out retrospectively and 84 patients participated from March 2016 to April 2019 who suffered acute ischemic stroke and were treated by endovascular treatment at this stroke center. The laboratory test and clinical data were assessed for the prognosis of acute ischemic stroke by endovascular treatment. An independent relationship was analyzed through binary logistic analysis and receiver operating characteristic curves for the accuracy of the test.Results This retrospective study was carried out at Harbin Medical University’s Second Affiliated Hospital, and enrolled 84 patients from March 2018 to September 2019, including 32 patients in whom the outcomes were clinically favorable and 52 patients with unfavorable clinical outcomes. The groin puncture to recanalization time significantly varied between patients with favorable as well as unfavorable clinical outcomes (45.0 min vs 72.5 min, p = 0.001), serum iron (10.87 μmol/L vs 4.07 μmol/L, p < 0.001) and thrombin time (13.40 s vs 14.25 s, p = 0.034) from univariable analysis. Serum iron (p < 0.001; adjusted OR [95% CI]:70.765 [9.904 - 505.636]) was associated independently with acute ischemic stroke prognosis by endovascular treatment, and receiver operating characteristic showed area under the curve of 0.926 (p < 0.001, 95% CI: 0.872 - 0.979).Conclusions The outcomes of this study reveal that serum iron level was associated independently with acute ischemic stroke prognosis, and high serum iron level could predict favorable clinical outcomes with a significantly accurate ability. Thus, serum iron could be a marker for acute ischemic stroke prognosis through endovascular treatment.