Prevalence of chronic renal insufficiency in the Chinese population: A cross-sectional study

Abstract Background: The prevalence of chronic kidney disease (CKD) is increasing worldwide, and it has become a global health issue with a high economic burden. Chronic renal insufficiency (CRI), the most severe form of CKD, is associated with increased risks of cardiovascular disease, premature mortality, and decreased quality of life. However, epidemiological information on Chinese patients with CRI is still lacking. This study aimed to investigate the prevalence and epidemiological features of CRI in China. Methods: A total of 395,541 individuals aged ≥ 18 years residing in Binhai county, China were enrolled. e estimated the prevalence of CRI adjusting for age and sex. Associations of age, sex, blood pressure, body mass index, heart rate, and fasting blood glucose and triglyceride levels with CRI were examined. Odds ratios were calculated using a binary logistic regression model. Data were obtained from the records of universal health examinations of Binhai county residents conducted from January to December 2018. Results: The overall adjusted prevalence of CRI was 1.10% (95% confidence interval [CI], 1.07%-1.13%) in this Chinese adult population. The prevalence was 0.86% among men (95% CI, 0.82%-0.90%) and 1.34% among women (95% CI, 1.29%-1.39%). Female sex, age (per 10-year increase), central obesity, triglyceride levels (per 118-mg/dl increase), systolic blood pressure (per 10-mmHg increase), heart rate (per 10-beats/min increase) and fasting blood glucose ≥ 100 mg/dl were found to be independent risk factors for CRI. Conclusions: The overall prevalence of CRI in Chinese adults was 1.10%. Age, female sex, central obesity, higher triglycerides, SBP, heart rate and elevated fasting glucose levels were all independent risk factors associated with decreased eGFR. Health policies to prevent CRI are urgent among this population.