The Failure Risk of Surgical Therapy for Corneal Perforations Using Cryopreserved Donor Corneas

Abstract Background To evaluate the long-term results of therapeutic keratoplasty for a consecutive case series of corneal perforation.Methods The cases comprised 41 eyes (41 patients) that underwent therapeutic keratoplasty using cryopreserved donor grafts at the Keio University Hospital between January 2012 and December 2016. The eyes were evaluated regarding the cause of corneal perforation, surgical procedure, size of the perforation, presence of anterior chamber collapse, visual prognosis, and complications.Results The major causative diseases included herpetic keratitis (n = 11), bacterial and fungal corneal ulcer (n = 4), Mooren’s ulcer (n = 5), severe dry eye (n = 4), and neuroparalytic keratitis (n = 4). Penetrating keratoplasty was performed in 28 eyes (68.2%), lamellar keratoplasty in 8 eyes (19.5%), and keratoepithelioplasty in 5 eyes (12.2%).