Identification of new hit to lead magmas inhibitors as potential therapeutics for glioblastoma

Bhaskar C. Das,Javier J. Lepe,Mohammed Adil Shareef,Naomi Lomeli,Sasmita Das,Daniela A. Bota

Bioorganic & Medicinal Chemistry Letters（2023）

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摘要

A series of seventeen BT#9 analogues were designed, synthesized, characterized and tested for their anti-glioblastoma potential. Among them, BT-851 and BT-892 displayed promising anti-glioma effect and could serve as templates for magmas inhibitors in the future.

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